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With the increase in the portfolio of poorly soluble drugs within the pharmaceutical industry, the amorphous phase looks like a plausible approach to successfully bring these important drug candidates to the market. However, amorphous pharmaceuticals are difficult to control as the current understanding of these materials is limited. One reason for this is that the amorphous phase is inherently difficult to characterise and/or predict. While current techniques are capable of probing specific attributes, there is no simple technique that allows an effective understanding of these systems below the glass transition temperature.

This PhD will exploit the unique capabilities of thermally stimulated current (TSC) spectroscopy to characterise amorphous drug substances, which may include excipients and final products. Therefore, this project aims to develop selective and sensitive TSC methodologies to address common characterisation and quantification challenges experiences with full and partially amorphous (semi-crystalline) drug substances. This would then be used to better evaluate the suitability of amorphous materials throughout the whole drug development until launch and beyond.