Discipline: Clinical Sciences
We are the home of clinical and experimental medical research at ¿Û¿Û´«Ã½ and the nucleus of the growing body of medical research at the University. We aim to provide a central connecting point for researchers, clinical academics and partnering NHS trusts.
Our research ranges from basic to translational science, including first use of molecules in humans (Phase I trials) all the way through to real-world evidence studies using routinely collected data and extending to clinical practice guidelines, and patient and public engagement.
Discover our research
Cardiovascular Sciences
The multidisciplinary research in the Section of Cardiovascular Sciences encompasses a wide range of overarching disciplines and expertise, including Pharmacology, Epigenetics, Drug development and Physiology.
Clinical Medicine
The multidisciplinary research in the Section of Clinical Medicine drives the development of early detection and innovative interventions to prevent disease and improve the care of patients.
Oncology
The Section of Oncology is home to the . One focus is viral engineering for cancer vaccine development, the role of the microbiome in cancer and to be at the forefront of testing and developing novel technologies to investigate the tumour immune microenvironment, fundamental to developing cancer immunotherapies in the future.
Statistical Multi-Omics
The Section of Statistical Multi-Omics focuses on the dissection of the genetic architecture and multiple omics data layers for complex human and animal characteristics and their relations to symbiotic microbiota. The researchers develop novel statistical methods for multi-phenotype analysis, CNV detection, sequencing studies and multi-omics data.
¿Û¿Û´«Ã½ Health Economics Centre
The ¿Û¿Û´«Ã½ Health Economics Centre (SHEC) supports applied research in health, medicine and social care, working closely with the ¿Û¿Û´«Ã½ Clinical Trials Unit. The Centre leads on health economics for the NIHR Research Design Service South-East and the NIHR Applied Research Collaboration across Kent, ¿Û¿Û´«Ã½ and Sussex.
¿Û¿Û´«Ã½ Clinical Research Facility
The ¿Û¿Û´«Ã½ Clinical Research Facility (CRF) is a core human research resource recognised as a centre of excellence for the delivery of clinical trials and studies involving participants.
¿Û¿Û´«Ã½ Clinical Academic Network
The ¿Û¿Û´«Ã½ Clinical Academic Network (SCAN) is a recently founded initiative to bring together researchers, academics and clinicians from academia and healthcare in the region.
Head of Discipline
Dr Mark Crabtree
Senior Lecturer in Cardiovascular Biochemistry
Biography
Dr Mark Crabtree is a Senior Lecturer in the School of Biosciences, Faculty of Health and Medical Sciences. After completing his BSc here at the ¿Û¿Û´«Ã½, Mark did his PhD with Professor Steven Gross at Weill Medical College of Cornell University in New York, USA. In 2006 he moved to a Postdoctoral position with Professor Keith Channon in the Division of Cardiovascular Medicine at the University of Oxford. During his time in Oxford he held an Oxford Centre of Research Excellence Fellowship (2012-2014) and a British Heart Foundation Intermediate Fellowship (2015-2021). He returned to ¿Û¿Û´«Ã½ as a Senior Lecturer in 2022.
His research group focuses on understanding the mechanisms of nitric oxide and redox signalling in molecular models of cardiovascular disease. He has published over 60 original articles in word-leading journals, and his work has been cited over 3000 times. He is an Editorial Board member of the British Journal of Pharmacology and is a regular contributor to the peer review process for FRBM, Nitric Oxide, Cardiovascular Research, ATVB and Circulation Research.
Mark is an active council member for the Nitric Oxide Society and was the meeting Chair for the International Nitric Oxide Conference in Oxford, 2018.